STUDY OF TOXIC EFFECT OF METHIMAZOLE ON THE CORTICAL STRUCTURE OF ADULT MALE ALBINO RATS KIDNEYS AND THE AMELIORATED EFFECT OF THYROXIN
Abstract
Kidney and thyroid functions interact with each other. Drugs used in treatment of any of them could have
side reactions on any other organ. The effects of antithyroid medications on extrathyroidal organs could be
due to oxidative stress and to damage in the renal cells.
Aim: This work is designed to demonstrate the role of T4 in protection against the increase in
oxidative stress caused by methimazole, and to detect if antithyroid drug-induced hypothyroidism
(methimazole) or removal of thyroid by surgery causes damage of kidney cells or not.
Methods: Twenty-five healthy adult male albino rats were used in the study. The animals were randomly
separated into groups. Each group contained five rats: Group I (control group): This group received no drugs
or treatment. Group II included rats with false thyroidectomy. Group III included thyroidectomized albino
rats. Group IV included methimazole-induced hypothyroidism albino rats through receiving 60 mg/kg/day of
methimazole in drinking water. Group V were administered methimazole (60 mg/kg/day) and l-thyroxine
(T4) subcutaneous injection (20 μg/kg/day).The animals were anasethized and their abdomens were opened
and both kidneys were removed, and immediately processed for histological & immunohistochemical study.
Also oxidative enzymes were estimated.
Rresults: Light microscopic examination of H&E stained sections showed marked damage of the structure of
renal cortex in methimazole induced hypothyroidism group. This damage was concomitant with a decrease
in kidney antioxidant enzymes. This damage was less pronounced in group of rats administrated T4 in
association with methimazole. The cortex of kidney in rats of thyroidectomized group did not show any
alterations in its micro structure.
Conclusion: Methimazole causes both of hypothyroidism and alteration of the kidney cortex. This alteration
is not noticed in case of surgical thyroidectomy inducing hypothyroidism. L-Thyroxine (T4) could decrease
the effect of methimazole on kidney cortex.
Keywords: Methimazole, hypothyroidism, thyroidectomy, kidney cortex.
side reactions on any other organ. The effects of antithyroid medications on extrathyroidal organs could be
due to oxidative stress and to damage in the renal cells.
Aim: This work is designed to demonstrate the role of T4 in protection against the increase in
oxidative stress caused by methimazole, and to detect if antithyroid drug-induced hypothyroidism
(methimazole) or removal of thyroid by surgery causes damage of kidney cells or not.
Methods: Twenty-five healthy adult male albino rats were used in the study. The animals were randomly
separated into groups. Each group contained five rats: Group I (control group): This group received no drugs
or treatment. Group II included rats with false thyroidectomy. Group III included thyroidectomized albino
rats. Group IV included methimazole-induced hypothyroidism albino rats through receiving 60 mg/kg/day of
methimazole in drinking water. Group V were administered methimazole (60 mg/kg/day) and l-thyroxine
(T4) subcutaneous injection (20 μg/kg/day).The animals were anasethized and their abdomens were opened
and both kidneys were removed, and immediately processed for histological & immunohistochemical study.
Also oxidative enzymes were estimated.
Rresults: Light microscopic examination of H&E stained sections showed marked damage of the structure of
renal cortex in methimazole induced hypothyroidism group. This damage was concomitant with a decrease
in kidney antioxidant enzymes. This damage was less pronounced in group of rats administrated T4 in
association with methimazole. The cortex of kidney in rats of thyroidectomized group did not show any
alterations in its micro structure.
Conclusion: Methimazole causes both of hypothyroidism and alteration of the kidney cortex. This alteration
is not noticed in case of surgical thyroidectomy inducing hypothyroidism. L-Thyroxine (T4) could decrease
the effect of methimazole on kidney cortex.
Keywords: Methimazole, hypothyroidism, thyroidectomy, kidney cortex.
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